PDRN Advanced Infusion Treatment

Many users notice smoother, more hydrated skin after just one treatment — often describing a fresh glow and softer texture within 24–48 hours. That’s because the micro-infusion process immediately boosts hydration and wakes up your skin’s repair response.

However, for visible, lasting improvement, we recommend completing at least 6 treatments over 3 months.

Regular use may help support a firmer, more radiant look over time.

Consistency matters more than speed — and we’re here to support you through that journey.

It combines precision micro-infusion with a clinically proven collagen-boosting serum powered by PDRN.

The ultra-fine, painless 24K gold needles create micro-channels in your skin, allowing the serum to reach the deeper layers where collagen loss and structural changes cause wrinkles and sagging.

This process stimulates new collagen and elastin production, helping to lift, firm, and smooth the skin from within — for a more youthful, resilient complexion over time.

Each Micro Infusion System includes single-use sterile microneedle heads and serum vials.

1-Month Supply → 2 treatments (2 needle heads and 2 serum vials)
2-Month Supply → 4 treatments (4 needle heads and 4 serum vials)
3-Month Supply → 6 treatments (6 needle heads and 4 serum vials)

We recommend one session every 2 weeks to give your skin time to regenerate properly. This rhythm supports long-term collagen activation and minimizes irritation.

After each session, it is recommended to dispose of the used needle head and apply any remaining serum on your skin.

Each order comes with an easy to follow step-by-step video guideline.

The device uses ultra-fine, sterile 24K gold microneedles designed to gently penetrate only the uppermost layer of skin.

While they are long enough to trigger collagen and increase serum absorption, they are also thinner than a human hair, which makes the treatment very tolerable — even for beginners.

You might feel a light tingling or pricking during application, especially in more sensitive areas. But there’s no dragging, tearing, or numbing required.

Most people describe it as a gentle tapping sensation — and get used to it within seconds.

Smoothe's micro-infusion system uses microneedles that are 0.5mm in length — ideal for what's called “epidermal needling.”

This depth allows the serum to reach the upper dermis — the layer where fine lines begin and skin firmness starts to decline — without causing pain or requiring medical supervision.

It’s long enough to:
- Stimulate collagen and elastin production
- Boost skin cell renewal for smoother texture
- Enhance absorption of active ingredients up to 30× more effectively than topical application

At the same time, it's short enough to avoid bleeding or downtime, making it perfectly safe for at-home use — even for beginners.

Yes. Our formula and delivery system are both designed to be non-comedogenic, non-irritating, and safe for all skin types and tones.

We don’t use harsh acids, retinoids or bleaching agents. If your skin is extremely reactive, we recommend a patch test first, or consulting a dermatologist.

Yes — while it’s designed to target fine lines, wrinkles, and loss of firmness, the same technology can help improve the appearance of acne scars.

Our ultra-fine, painless 24K gold needles create micro-channels in the skin, allowing the PDRN-powered serum to reach the deeper layers where both aging and scar texture originate.

This stimulates collagen production, refines texture, and can visibly reduce the look of shallow scars over time.

We recommend waiting until active breakouts have calmed before using the device.

Using microneedles on inflamed or broken skin may lead to irritation or delayed healing.

Yes — it can be safely used on the neck, lips, and most areas of the body where you want to improve skin texture, smooth fine lines, or boost firmness.

Many users apply it also to areas with:
- Crepey skin on the décolleté
- Fine lines and loss of firmness along the neck and jawline
- Textural irregularities or dryness on the arms or hands

For sensitive zones like lips and neck, apply with light pressure and follow our guided stamping technique.

However, avoid using the device directly on the eyelids or waterline. We recommend keeping at least 1.5 inches (around 3 cm) away from the eyes to protect delicate skin.

Every order includes a detailed step-by-step video guide to show you exactly how and where to apply it for best results.

After each treatment, your skin is in “recovery mode” — and also more receptive to anything you apply. To protect your results and avoid irritation, we recommend the following:

First 24 hours:

- Avoid makeup, sun exposure, and sweating (no gym, sauna or steam)
- Do not apply active ingredients like retinol, acids, scrubs, or exfoliants
- Keep skin clean and hydrated using a gentle, fragrance-free moisturizer
- Try not to touch your face, especially with unwashed hands

Day after:

- Wash your face with a mild cleanser, pat dry, and moisturize
- If you go outside, apply a high-quality, non-comedogenic SPF

What’s normal:

It’s common to experience light redness, dryness or a tight feeling for a few hours. Some users may notice slight flaking or peeling a few days later — a sign your skin is renewing.

Pro tip:

Your skin absorbs ingredients up to 3x better after infusion, so avoid applying anything harsh during this window. Stick to calming, barrier-repair formulas only.

Most users return to their full skincare routine within 48 hours — but you may not even feel the need for much. The serum does most of the work.

Yes — but with a few important guidelines. Right after your treatment, your skin is more permeable and sensitive. This means ingredients absorb better, but it also makes your skin more reactive.

Here’s what you can use:

- Hyaluronic acid or hydrating moisturizers: apply in the evening after treatment to boost hydration and support healing
- Fragrance-free, calming creams (e.g., with panthenol, ceramides, or Centella) are also recommended

Here’s what to avoid for 24–48 hours:

- Retinol (Vitamin A)
- Exfoliating acids (glycolic, lactic, salicylic)
- Vitamin C serums, scrubs, or strong actives
- Any skincare with fragrance or alcohol

It’s simple and takes just a few minutes. Whether you're new to skincare or an experienced user, you’ll find the process easy to follow — and incredibly rewarding. Here’s how it works:

1. Prep Your Skin

Start with a freshly cleansed face. Gently pat dry and ensure your skin is free of any products.

2. Attach & Prime

Twist the serum vial directly onto the microneedle head. Then hold the device upside down for about 2 minutes, allowing the serum to fully saturate the needles.

3. Stamp & Infuse

Gently press the device onto your skin, beginning at the center of the face and working outward. Use a 50% overlap between stamps, and repeat 2–3 passes over areas prone to fine lines, wrinkles, or loss of firmness. Avoid stamping directly over active breakouts.

4. Let It Absorb

Pat any leftover serum onto your face and neck. Leave the serum on overnight, and avoid makeup or sun exposure for the next 24 hours.

The entire treatment takes 5–10 minutes. Every order includes a step-by-step video guide to help you use it with confidence — even if it’s your first time.

No — and you shouldn't.

Each microneedle head is sterile and single-use, just like in clinical settings. Reusing the same head compromises hygiene, blunts the needles, and increases the risk of irritation or infection.

We include a fresh head for each treatment — no need to guess or clean.

We don’t recommend using third-party serums. The SMOOTHE formula was developed to work with micro-infusion: it’s lightweight, fast-absorbing, and enriched with actives like PDRN, Niacinamide, and Panthenol.

Other serums may contain irritants or molecules too large to penetrate through micro-channels — wasting your treatment or even causing sensitivity.

Once you’ve reached your desired results, you don’t need to use it as often — many switch to a maintenance rhythm, like once a month.

The results typically last several weeks, depending on your skin type, age, and skincare routine. Regular use helps prolong and maintain the effect over time.

Rollers create micro-injuries — but don’t deliver ingredients into the skin.

Our Micro Infusion System not only creates the micro-channels, it also infuses a clinically active serum directly where aging forms.

Plus:

- It uses sterile, single-use heads
- Rollers often get reused, increasing risk of irritation & bacteria
- Our stamping mechanism is more precise, less damaging
Attracts and locks in water to soften and protect your skin’s surface against dryness.

Yes, but we suggest waiting at least:
- 2 weeks after fillers / Botox
- 4/6 weeks after laser treatments

And as always — check with your dermatologist if you're under clinical care.

No extensive prep needed. Just clean your face thoroughly, make sure your hands are clean, and you're good to go.

Optionally, apply a gentle toner or hydrating mist before starting to help serum spread evenly.

Our money-back guarantee ensures that if you are not satisfied with your purchase, you can return the item within 90 days of receipt for a full refund.

Simply contact our customer service team to initiate the return process, and follow the provided instructions.

Once we receive the returned item, we will process your refund within 5-7 business days.

For returns, please email us at info@smootheskincare.com